慢性鼻炎的缓解与生物治疗的鼻息肉:一个现实生活的经验
Antonella Loperfido1, Carlo Cavaliere2, Andrea Ciofalo2
1Otolaryngology Unit, San Camillo Forlanini Hospital, Circonvallazione Gianicolense 87, Rome, 00152, Italy. aloperfido@scamilloforlanini.rm.it.
概括
杜皮卢马布治疗显著改善了严重的长期鼻炎与鼻息肉 (CRSwNP) 的症状和生活质量. 很高比例的患者实现了疾病缓解,这表明了潜在的疾病修饰.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
背景情况:
- 生物药物为带有鼻息肉的慢性鼻炎 (CRSwNP) 提供了疾病修饰的潜力,将治疗目标转向缓解.
- 在CRSwNP中,缓解是通过持续控制症状和至少12个月没有活跃疾病来定义的,根据EPOS2020/EUFOREA指南.
研究的目的:
- 为了识别患有严重CRSwNP的患者,他们在杜皮卢马布治疗两年内实现了疾病缓解.
- 评估dupilumab在严重,不受控制的CRSwNP中的有效性和安全性.
主要方法:
- 一项回顾性观察性研究评估了30名患有严重CRSwNP的患者,持续了24个月.
- 收集的数据包括鼻息肉得分 (NPS),症状,嗅觉功能,生活质量 (QoL) 和安全参数.
- 缓解评估考虑了EPOS2020/EUFOREA专家小组的建议.
主要成果:
- 杜皮卢马布治疗导致NPS显著降低,症状严重程度以及嗅觉功能和QoL的改善.
- 77%的患者 (30人中有23人) 实现了疾病缓解.
- 评估了dupilumab的安全性概况,包括副作用和乙氨基酸血清.
结论:
- 杜皮卢马布在治疗严重的2型炎症驱动的CRSwNP方面表现出有效性,缓解率高.
- 对于CRSwNP管理,需要对更大的队列和标准化缓解标准进行进一步的研究.
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