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Updated: Sep 12, 2025

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开发一种NADPH再生系统,用于Escherichia coli中的L-氨酸生产

Xiaoping Luo1, Buli Su1, Peixuan Lai1

  • 1Key Laboratory of Agricultural Microbiomics and Precision Application (MARA), Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Key Laboratory of Agricultural Microbiome (MARA), State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070, People's Republic of China.

Applied biochemistry and biotechnology
|August 4, 2025
PubMed
概括

我们开发了一种NADPH再生系统,以提高L-氨酸的产量. 这种系统通过基因修改优化NADPH可用性,显著增加了L-氨酸的产量.

关键词:
这是一种L-threonine,一种L-threonine.这就是Pgi的意义.这就是CRISPR-Cas12f1的原因.在NADPH再生系统.发起人工程 发起人工程

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Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
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