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Quantitative Autonomic Testing
Published on: July 19, 2011
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在儿童群体中,怀疑反射失眠的儿童群体中,用酸甘增强的头向上倾斜试验的诊断产量
Vincenzo Russo1, Angelo Comune2, Giangiacomo Di Nardo3
1Cardiology and Syncope Unit, Department of Translational Medical Sciences, University of Campania Luigi Vanvitelli, Monaldi Hospital, Via Leonardo Bianchi, Naples, Italy. vincenzo.russo@unicampania.it.
概括
酸甘油 (NTG) 增强的头向上倾斜测试 (HUTT) 是有效的诊断儿童的反射失眠,显示高的阳性率和良好的准确性. 年龄较小和女性性别预测了儿科昏迷患者的积极结果.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 自主神经系统障碍 自主神经系统障碍
- 诊断测试 诊断测试 诊断测试
背景情况:
- 昏迷是儿科患者常见的疾病,需要准确的诊断方法.
- 酸甘油 (NTG) 增强的头向上倾斜测试 (HUTT) 已被确立用于诊断成年人的反射失眠,但儿科数据有限且相互矛盾.
- 这项研究解决了评估NTG增强HUTT在疑似反射失眠的儿科患者群体中的功效的需要.
研究的目的:
- 评估NTG增强型HUTT的阳性率和响应模式,用于疑似反射失眠的儿科患者.
- 在这个人群中确定NTG增强HUTT的诊断准确性 (灵敏度和特异性).
- 确定与儿童积极HUTT反应相关的临床因素.
主要方法:
- 一项回顾性多中心分析包括307名在两个昏迷单位接受HUTT的儿科患者.
- 为了进行比较,使用了一个由16名健康儿科患者组成的对照组,没有昏迷史.
- 收集和分析了关于HUTT阳性率,反应类型,敏感性,特异性和临床共变量的多变量分析的数据.
主要成果:
- 儿科患者的整体HUTT阳性率为74.9%,根据昏迷呈现的变化 (51.5%非经典到81.6%经典).
- 对照组的阳性率为18.7%,HUTT特异性为81.3%.
- 年龄较小 (OR:0.84) 和女性性别 (OR:2.3) 是HUTT阳性的独立预测因素,而非经典呈现 (OR:0.23) 和情境 (OR:0.2) 与负相关.
结论:
- 增强NTG的HUTT显示了高的阳性率,良好的灵敏度和特异性,用于诊断儿科患者的反射失眠.
- 特定的患者和昏迷相关的特征独立地与HUTT阳性相关.
- 心脏抑制反应在患有非经典表现的反射失眠的儿科患者中更为频繁.
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