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在男性吸烟者中改变了半球间和半球内功能连接动态

Mengzhe Zhang¹, Huiyu Huang¹, Xiaoyu Niu¹

¹Department of MRI, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

|August 4, 2025

概括

这项研究揭示了吸烟者的独特大脑连接模式,突出了动态功能连接的半球差异. 这些发现为烟草使用障碍的神经基础提供了新的见解.

科学领域:

神经科学是一个神经科学.
成研究研究成研究
脑部成像脑部成像

背景情况:

以前关于烟草使用障碍 (TUD) 的研究在很大程度上忽视了半球差异和时间大脑动态.
全脑分析限制了对半球层面的动态功能连接的理解.

研究的目的:

在TUD患者中研究半球动态功能连接 (dFCD) 的半球差异.
探索dFCD变化和吸烟依赖程度之间的关系.

主要方法:

分析了来自70名吸烟者和40名非吸烟者的rs-fMRI数据.
通过动态功能连接密度 (dFCD) 的变化来评估半球间和半球内部的功能连接.
相关性分析检查了dFCD变化和吸烟临床尺度之间的联系.

主要成果:

吸烟者在双边视觉皮层中表现出共同的dFCD变异性.
高依赖性吸烟者表现出左侧胰岛的半球间dFCD变异性增加,右侧下额回形 (IFG) 和下额叶 (IPL) 的半球内dFCD变异性降低.
在高依赖性吸烟者中右IPL内半球dFCD变化与身体依赖相关.

结论:

这项研究确定了吸烟者的视觉皮层和前端双相网络中独特的inter/intra-hemispheric dFCD变异性.
研究结果表明,在TUD中,半球专业化和半球间交流发生了变化.
这项研究从动态角度提供了对TUD中大脑功能异常的新见解.

关键词:

动态动态动态动态功能连接密度的功能连接密度.在半球间/半球内.严重程度严重程度烟草使用障碍烟草使用障碍

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