心肌梗塞在多模式头癌治疗中的全球发病率和死亡率:系统性审查和元分析
Ameya A Asarkar1, Srivatsa Surya Vasudevan2, Veronica Fernandez-Alvarez3
1Department of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Shreveport, 1501 Kings Highway, Shreveport, LA, 71103, USA. ameya.asarkar@lsuhs.edu.
Advances in therapy
|August 5, 2025
概括
头癌治疗后心肌梗塞 (MI) 的发生率为1.7%,随着时间的推移而下降. 心血管疾病死亡率仍然很高,为42.1%,强调需要改善患者监测.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 头癌 (HNC) 治疗涉及多种模式的方法.
- 在HNC治疗后,心肌梗塞 (MI) 发生率和死亡率存在显著差异.
研究的目的:
- 系统地审查和分析HNC患者的MI发病率和死亡率.
- 根据治疗方式,时间段和地理位置,确定影响心脏病发作率的因素.
主要方法:
- 在主要数据库 (PubMed,Embase,ScienceDirect,Web of Science) 进行全面的文献搜索.
- 包括53项研究,包括85,948名HNC患者.
- 随机效应元分析和子组/元回归分析.
主要成果:
- 全球综合性心脏病发病率:1.7% (从2010年前的2.6%下降到2010年后的1.5%).
- 仅通过手术的MI发病率最低 (1.2%);使用组合疗法或RT/CRT时更高.
- 全球综合性心脏病发作死亡率:42.1% (从2010年之前的49.8%下降到2010年后的36.0%).
结论:
- 在HNC治疗后的MI发病率为1.7%,仅仅手术后的发病率最低,没有显著的地理差异.
- 心肌梗塞的死亡率很高 (42.1%),但正在下降,这凸显了HNC治疗对心血管的负担.
- 有针对性的心血管监测至关重要,特别是对于非手术治疗方式.
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