通过辅助生殖技术怀孕的早产婴儿的围产生长和神经发育结果:一项回顾性比较队列研究
Shan He1,2, Jian-Hua Yu3, Xiao-Zhi Xu1,2
1Department of Pediatric, The First People's Hospital of Yunnan Province, No. 157, Jinbi Road, Kunming, 650032, China.
Journal of assisted reproduction and genetics
|August 5, 2025
概括
通过辅助生殖技术 (ART) 怀孕的早产婴儿在幼儿时期的生长和发育得分比自发怀孕的婴儿低. 这凸显了需要密切监测和早期干预ART怀孕婴儿的需要.
科学领域:
- 新生儿研究新生儿研究
- 发育儿科 发育儿科
- 生殖医学是一种生殖医学.
背景情况:
- 辅助生殖技术 (ART) 越来越多地用于怀孕.
- 过早出生的婴儿面临着独特的生长和发育挑战.
- 了解ART对早产婴儿结果的影响至关重要.
研究的目的:
- 为了比较增长参数 (头周长,长度,体重) 和神经发育的结果,在早产婴儿怀孕通过ART与自发受孕.
- 用吉塞尔发育表格来评估发育表现.
主要方法:
- 倾向分数匹配 (PSM) 用于控制ART和非ART组之间的基线差异.
- 增长被测量在出生时,1个月和3个月.
- 神经发育被评估在1,2,3年使用吉塞尔尺度.
- 总共有290名早产婴儿 (每组145名) 在PSM后被分析.
主要成果:
- 在1个月和3个月时,ART孕育的婴儿头周,长度和体重显著降低.
- 接受ART治疗的婴儿在1岁和2岁时表现出明显较低的发育分数.
- 在PSM后,基线特征在两组之间是可比的.
结论:
- 通过ART怀孕的早产婴儿与自发怀孕的同龄人相比,表现出较差的早期生长和发育轨迹.
- 积极的临床监测和有针对性的早期干预措施对于优化ART怀孕过早婴儿的结果至关重要.
- 需要进一步研究长期影响和具体干预措施.
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