评估环境空气污染对出生结果的影响:苏格兰试管婴儿队列研究 (2010 - 2018)
Haoze Song1, Tom Clemens2, Ruth M Doherty2
1University of Edinburgh, School of Geoscience, School of GeoSciences, University of Edinburgh, Edinburgh, UK. haoze.song@ed.ac.uk.
Environmental health : a global access science source
|August 5, 2025
概括
在怀孕早期暴露于空气污染与不良分娩结果有关. 在试管婴儿患者中,颗粒物和二氧化增加了早产,低出生体重和妊娠年龄较小的风险.
科学领域:
- 环境健康 环境健康
- 生殖科学 生殖科学
- 围产期流行病学 围产期流行病学
背景情况:
- 在怀孕前和怀孕期间暴露于环境空气污染与不良分娩结果有关.
- 试管婴儿 (IVF) 数据提供了一个独特的队列来研究这些关联.
研究的目的:
- 调查环境空气污染暴露与接受试管婴儿治疗的妇女的不良分娩结果之间的联系.
- 在试管婴儿过程中识别关键暴露窗口.
主要方法:
- 在四个与试管婴儿相关的窗口中分析每日平均空气污染 (PM10,PM2.5,NO2) 暴露.
- 使用大气分散模型系统 (ADMS-Urban) 来估计污染,与试管婴儿患者邮政编码联系在一起.
- 后勤回归模型被用来评估与低出生体重,怀孕年龄小,早产,控制混因素的关联.
主要成果:
- 在前两个试管婴儿窗口 (产卵前检索和产卵前激素药物治疗) 期间的暴露没有发现显著的关联.
- 在窗口3 (胚胎转移后) 和窗口4 (转移到分娩) 中增加的PM10与早产的更高几率相关.
- 窗口3期间NO2的增加与出生体重较低和妊娠年龄较小的更高几率有关.
结论:
- 在怀孕的早期阶段,特别是怀孕后14天暴露于空气污染,代表了增加出生不良结果风险的关键窗口.
- 与细胞内注射精子 (ICSI) 组相比,试管婴儿组可能更容易受到空气污染的影响.
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