相关实验视频

Updated: Sep 12, 2025

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

循环的托芬代谢物与腰椎间盘椎间盘手术中的术后疼痛强度之间的关联:一项观察性研究

Yunus Celik¹, Hale Aksu¹, Ferim Sakize Gunenc¹

¹Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylul University, Izmir, Turkey.

|August 5, 2025

概括

研究肠道微生物群的研究.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
免疫学免疫学免疫学

背景情况:

肠道微生物群影响疼痛调节,但其在手术疼痛中的作用未得到充分研究.
托衍生代谢物是神经免疫相互作用的关键媒介.

研究的目的:

探索循环托代谢物与急性术后疼痛强度之间的关联.
为了确定潜在的生物标志物来评估腰椎间盘的手术后的疼痛.

主要方法:

在37名接受腰椎间盘椎间盘外科手术的患者中进行了观察性研究.
使用LC-MS/MS. 量化了七种托芬代谢物 (皮科林酸,3-OH 基努伦因,3-OH 基努伦因,3-OH 基努伦因,3-OH 基努伦因,3-OH 基努伦因,3-OH 基努伦因,3-OH 基努伦因,3-OH 基努伦因,3-OH 基努伦因,3-OH 基努伦因,3-OH 基努伦因,3-OH 基努伦因,3-OH 基努伦因,3-OH 基努伦因) 的数量.
代谢物水平与视觉模拟尺度 (VAS) 疼痛评分之间的相关性分析.

主要成果:

在皮科林酸,金酸和香酸水平中观察到显著的外科手术前变化.
奇诺林酸水平与24小时术后VAS疼痛得分正相关 (r=0.422,P=0.009).
年龄和操作时间与特异性托代谢物的变化有关.

结论:

特定的托芬代谢物,特别是林酸,与术后疼痛强度有关.
这些代谢物可以作为潜在的生物标志物,用于评估手术患者的疼痛.
需要进一步研究直接微生物群概况,以阐明潜在的机制.

关键词:

剧烈的疼痛是急性疼痛.基努伦酸是什么基努伦酸是什么基努伦酸是什么我们的微生物群.皮科林酸是什么皮科林酸是什么奇诺林酸是一种氨酸.托芬三聚氨酸是什么桑氨酸是一种氨酸.

更多相关视频

Full-Endoscopic Isolation Zone Technique for the Treatment of Lumbar Disc Herniation

Full-Endoscopic Isolation Zone Technique for the Treatment of Lumbar Disc Herniation

Published on: April 7, 2023

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

Published on: July 21, 2023

相关概念视频

Analgesia and Pain Management

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

Local Anesthetics: Clinical Application as Spinal Anesthesia

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...