在慢性自发性疹中降低25-氧维生素D水平及其与疾病活动的关系
Tuğba Songül Tat1,2, Güzin Özden3, Fatma Tat4
1Allergy and Immunology Unit, Gaziantep Medical Point Hospital, Gaziantep, Turkey.
Medicine
|August 5, 2025
概括
慢性自发性疹 (CSU) 患者的维生素D水平比健康人低. 然而,在这项研究中,维生素D水平与CSU疾病严重程度没有相关性.
科学领域:
- 皮肤病学 皮肤病学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 慢性自发性疹 (CSU) 显著影响患者的生活质量.
- 在CSU的疾病活动受到各种因素的影响,包括潜在的营养缺乏.
- 维生素D缺乏症是一种广泛的疾病,对免疫功能有影响.
研究的目的:
- 调查血清25-基维生素D水平与CSU患者的疾病活性之间的关联.
- 为了比较CSU患者的维生素D水平与没有疹的对照组.
- 在CSU的不同严重程度小组中分析维生素D水平.
主要方法:
- 追溯分析CSU患者和对照组的医疗记录.
- 血清25-基维生素D水平通过电化学发光测量.
- 使用疹活动得分评估CSU疾病活性,将患者分为轻度,中度和重度组.
主要成果:
- 与对照组相比,CSU患者的血清维生素D水平明显较低 (17.55 ng/mL对比 26.06 ng/mL,P < .001).
- 在CSU小组中,维生素D平均水平为18.78 ± 9.78 ng/mL (轻度),16.22 ± 9.23 ng/mL (中度) 和17.65 ± 8.86 ng/mL (严重).
- 在轻度,中度和严重的CSU亚组之间没有观察到维生素D水平的统计学上显著差异 (P = .410).
结论:
- 诊断为慢性自发性疹患者的血清维生素D水平较低,与没有这种情况的患者相比.
- 尽管CSU患者的总体水平较低,但血清维生素D度在CSU小组内没有显示出与疾病严重程度的统计学显著相关性.
相关概念视频
Role of Skin in Vitamin D Synthesis
5.7K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.7K
Connective Tissue Cell Types
3.4K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.4K
Chronic Kidney Disease II: Clinical Manifestations
93
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
93
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
36
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
36
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
58
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
58


