相关实验视频

Updated: Sep 12, 2025

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

循环RNA PVT1作为人类癌症的潜在生物标志物:系统性审查和元分析

Xiaoyan Ma¹, Junheng Chen², Chunbin Zhou^3,4

¹Cancer Hospital of Shantou University Medical College, Guangdong, China.

The International journal of biological markers

|August 5, 2025

概括

循环RNA PVT1 (circPVT1) 对人类癌症具有很强的诊断准确性. 这种瘤性circRNA在许多癌症类型中受到上调,可以作为早期检测和管理的有希望的生物标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

循环RNAs (circRNAs) 是癌症发展和进展的关键调节者.
从PVT1基因衍生出的CircPVT1在各种人类癌症中经常被上调.
CircPVT1充当微RNA海绵,调节下游基因表达并影响恶性行为.

研究的目的:

评估circPVT1作为人类癌症生物标志物的诊断准确性.
综合现有关于circPVT1在不同癌症类型的诊断性能的证据.

主要方法:

在PubMed,EMBASE,Web of Science和Cochrane数据库中进行了系统的文献搜索,截至2024年7月.
使用随机效应模型进行了元分析.
通过接受器操作员特征 (ROC) 曲线分析评估诊断性能,包括按癌症类型和组织分类的亚组分析.

主要成果:

包括1246名患者的12项研究.
对circPVT1的综合敏感度为0.83 (95% CI,0.77-0.88) 和特异性为0.80 (95% CI,0.73-0.87).
在ROC曲线下的面积 (AUC) 为0.89 (95% CI,0.86-0.91),表明了强大的诊断值.

结论:

CircPVT1对人类癌症具有显著的诊断准确性.
这些发现支持circPVT1作为有前途的诊断生物标志物的潜力.
进一步了解circPVT1在癌症中的作用和机制得到了增强.

关键词:

生物标志物生物标志物癌症癌症癌症癌症癌症 circPVT1 的时间.环RNA 环RNA 是一个环RNA.hsa_circ_000182121 这是一个很好的例子.

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