中性粒细胞异质性确定了LAMP1与扩散性狼性炎的关联
Lennard Ostendorf1,2,3,4, Panagiotis Garantziotis5,6, Frank Y Huang7
1Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.
European journal of immunology
|August 5, 2025
概括
lysosomal相关膜蛋白1 (LAMP1) 在狼性炎 (LN) 中标记了激活的中性粒细胞,这是严重的狼并发症. 血清和尿液LAMP1的升高表明其作为早期LN检测和监测的非侵入性生物标志物的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物发现发现
背景情况:
- 狼性炎 (LN) 是一种严重的全身性红斑狼 (SLE) 症状,早期检测的生物标志物很少.
- 在SLE病原体中中性粒细胞的异质性尚未得到充分理解.
研究的目的:
- 为了确定狼性炎 (LN) 的新生物标志物.
- 在LN患者中表征中性粒细胞激活.
主要方法:
- 质量细胞测量用于对活检确认的增殖性LN和健康对照患者的血液中性粒细胞进行分析.
- 进行了转录组分析,以评估LAMP1 mRNA表达.
- 测量了血清和尿液中的LAMP1水平.
主要成果:
- 在LN患者中确定了一种表达表面 lysosomal-associated膜蛋白1 (LAMP1/CD107a) 的活性中性粒细胞的独特群体.
- 表面LAMP1表达反映了中性粒细胞的激活,而不是转录的增加.
- 溶性LAMP1在SLE患者血清中升高,特别是在增殖性LN中.
- 尿路LAMP1与LN患者损伤和疾病活动的关键指标相关.
结论:
- 溶解体相关膜蛋白1 (LAMP1) 作为SLE中中性粒细胞激活的标志物.
- 血清和尿液中的LAMP1显示为LN. proliferative的非侵入性生物标志物具有前途.
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