韦里西瓜特增强后传染性无氧症的嗅觉功能:一个随机试点双盲安慰剂受控试验
Adnan Alharbi1, Mohamed H Abdelazim2, Abdullah S Alshammari1
1Pharmaceutical Practices Department, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
American journal of rhinology & allergy
|August 5, 2025
概括
韦瑞西瓜特显著改善了后感染性厌氧症患者的嗅觉功能,增强了嗅觉值,区分和识别. 虽然在统计学上显著,但整体改善没有达到确定的临床值,以获得有意义的益处.
科学领域:
- 神经学 神经学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
背景情况:
- 嗅觉功能障碍影响~29%的人口,降低生活质量.
- 后感染性厌氧症缺乏有效的药理治疗方法.
- 韦瑞西瓜特是一种可溶性瓜尼酸环酶刺激剂,显示了与嗅觉相关的潜在神经调节效应.
研究的目的:
- 调查口服输送在改善上呼吸道感染后持久性厌氧症患者的嗅觉功能的疗效.
- 评估传感器对嗅觉值,歧视和识别的影响.
主要方法:
- 一个为期12个月的,双盲,随机对照试验,涉及88名患有后传染性厌氧症的参与者.
- 参与者接受了安慰剂或口服 vericiguat (4mg每天两次).
- 嗅觉功能每月使用嗅探棒测试 (门,歧视,识别) 进行评估.
主要成果:
- 与安慰剂相比,Vericiguat组在嗅觉值 (T),歧视 (D) 和识别 (I) 得分方面显示出统计学上显著的改善.
- 在D (4个月),T (6个月) 和I (7个月) 期间,组间的差异变得显著.
- 接受治疗的患者群体的平均总TDI改善 (3.19分) 没有达到5.5分的临床值.
结论:
- 与安慰剂相比,维里西瓜特在患有后感染性厌氧症的患者中显示了关键的嗅觉测量结果的统计学显著改善.
- 这些发现表明, vericiguat作为嗅觉功能障碍的药理疗法的潜力.
- 需要进一步的研究来探索 vericiguat对嗅觉的影响的机制和临床意义.
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