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氧化应激和肠道微生物群的相互作用加剧糖尿病小鼠的牙周炎

Haotian Gong¹, Linyue Zhang¹, Yangbo Liu¹

¹Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Stomatological Hospital of Chongqing Medical University, Chongqing, China.

Journal of clinical periodontology

|August 5, 2025

概括

氧化应激和肠道失生症在糖尿病中加剧牙周炎. 抗氧化剂治疗和便微生物群移植 (FMT) 显示出通过恢复肠道健康和减少炎症来治疗糖尿病牙周炎的前景.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
内分泌学在内分泌学.

背景情况:

糖尿病会加剧牙周炎,导致膜骨损失和炎症的增加.
系统性氧化应激和肠道失生症与糖尿病牙周炎的进展有关.

研究的目的:

在糖尿病小鼠中调查氧化应激,肠道微生物群和牙周炎之间的联系.
探索抗氧化疗法和便微生物群移植 (FMT) 作为糖尿病牙周炎的潜在治疗方法.

主要方法:

使用了糖尿病牙周炎小鼠模型.
干预措施包括抗氧化剂治疗 (黄素),共同住房和FMT.
评估的参数包括膜骨损失,炎症,氧化应激,肠道微生物群和肠道屏障功能.

主要成果:

糖尿病牙周炎小鼠的骨损失,炎症,氧化应激和肠道失生症增加.
黄素治疗改善了这些标志物.
同居和FMT证明了有益的肠道微生物群的转移,改善牙周健康并减少氧化应激.

结论:

一个涉及氧化应激和肠道失调的病原性循环加剧了糖尿病患者的牙周炎.
抗氧化剂治疗和FMT是治疗糖尿病牙周炎的有前途的辅助疗法.

关键词:

糖尿病糖尿病患者糖尿病患者肠道失调症是一种肠道失调症.主体微生物的相互作用.氧化应激是一种氧化应激.牙周炎是指牙周炎的一种疾病.

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