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产前接触双甲和2至5岁儿童的神经认知变化:系统性审查

Isabella Vian Matias de Oliveira¹, Fernanda Martins de Albuquerque², Amanda de Jesus Fernandes¹

¹Faculdade de Nutrição, Universidade Federal de Mato Grosso, Cuiabá, Brasil.

Reviews on environmental health

|August 5, 2025

概括

产前暴露于内分泌干扰物Bisphenol-A (BPA) 与2-5岁儿童的不良神经认知发育有关. 这包括行为,注意力和认知功能的问题,观察到性别特异性差异.

科学领域:

环境健康环境健康
神经科学是一个神经科学.
发育儿科发育儿科

背景情况:

双-A (BPA) 是一种合成的内分泌干扰剂.
儿童BPA暴露与包括ADHD在内的认知和行为问题有关.
产前暴露是神经发育影响的关键窗口.

研究的目的:

系统地审查有关产前双A (BPA) 暴露和2-5岁儿童神经认知发育的文献.
综合关于母亲BPA暴露与儿童神经发育结果之间的关系的发现.
为了确定产前BPA暴露的性别特异性影响.

主要方法:

按照PRISMA指南进行系统审查 (PROSPERO CRD42023494940).
在没有日期限制的Web of Science,Embase和PubMed数据库中进行搜索.
包括21项纵向研究,检查产前BPA暴露和儿童神经发育.

主要成果:

大多数研究表明,产前BPA暴露对2-5岁儿童神经认知发育的负面影响.
观察到的性别差异:女性表现出较低的情绪控制和语言技能;男性表现出较低的精神运动发育.
产前BPA暴露与多动性,侵略性,焦虑,注意力不集中和睡眠障碍有关.

结论:

孕妇在怀孕期间接触双A (BPA) 会对2-5岁儿童的神经认知发育产生不利影响.
产前BPA暴露与一系列行为和认知障碍有关.
进一步的研究是有必要的,以了解性别特异性的脆弱性和长期影响.

关键词:

孩子们的孩子们的孩子们的孩子们.情绪调节失调,情绪失调.破坏内分泌的化学物质破坏内分泌的化学物质神经行为障碍神经行为障碍神经发育的神经发育怀孕怀孕怀孕怀孕怀孕怀孕

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