相关实验视频
Updated: Sep 12, 2025

06:53
Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
12.6K
HOXC6激活BCAT1的表达,促进口腔癌的发展
Meiheriban Tuerhong1, Zaynure Wubulihasimu1, Bo Xu2
1Department of Oral and Maxillofacial Surgery, Second People's Hospital of Kashi Prefecture, Kashi, Xinjiang, P.R. China.
Oral diseases
|August 5, 2025
概括
通过增加BCAT1的表达,HOXC6促进了口腔癌. 抑制HOXC6或BCAT1可以降低口腔癌细胞的生长,迁移,入侵和上皮细胞转移到介质细胞 (EMT),从而提供潜在的治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 口腔癌是全球重要的健康问题.
- 了解推动口腔癌进展的分子机制对于开发有效疗法至关重要.
研究的目的:
- 研究HOXC6在口腔癌发展中的作用.
- 阐明HOXC6和BCAT1.1之间的监管关系.
- 探索HOXC6-介导的口腔癌进展的潜在分子机制.
主要方法:
- 西部斑块和RT-qPCR用于评估BCAT1表达.
- 细胞增殖,迁移,入侵和细胞亡在BCAT1敲击后的测定.
- 生物信息学分析用于上游监管机制.
- 对于HOXC6表达的免疫组织化学.
- 染色体免疫沉 (ChIP) 和双酶试验证实了HOXC6-BCAT1促进体相互作用.
- 在体内异种移植瘤模型.
主要成果:
- 在口腔癌组织中,BCAT1和HOXC6都显著上调.
- 抑制BCAT1抑制了口腔癌细胞的增殖,迁移,入侵和上皮细胞转移到介质细胞 (EMT),同时促进了细胞亡.
- 降低HOXC6调节减弱了口腔癌的恶性表型和EMT.
- HOXC6直接与BCAT1促进体结合,导致其转录激活并促进口腔癌的进展.
- 沉默HOXC6导致BCAT1表达的降低.
结论:
- 在口腔癌中,HOXC6作为BCAT1的转录激活剂.
- 通过HOXC6调节BCAT1的上调驱动口腔癌的发展和进展.
- 准HOXC6-BCAT1轴为口腔癌提供了一个潜在的治疗策略.
相关概念视频
Hedgehog Signaling Pathway
7.5K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.5K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.2K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.2K
Canonical Wnt Signaling Pathway
8.9K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.9K
Induced Pluripotent Stem Cells
4.4K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
4.4K
Cancer-Critical Genes I: Proto-oncogenes
9.1K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.1K
Cadherins in Tissue Organization
3.1K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
3.1K

