多功能--生物陶树脂复合材料,用于增强牙重矿化和修复性牙形成
Peng Mei1, Xingyu Tao2,3, Ziduan Ding1
1Department of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, 200011, China.
一种新的酸树脂复合物有效地使牙重矿化,并刺激修复性牙生成. 这种生物活性物质对先进的牙重矿化和间接的肉质封闭疗法充满希望.
科学领域:
- 生物材料科学 生物材料科学
- 牙科研究 牙科研究
- 再生医学是一种再生医学.
背景情况:
- 深度病变可能会暴露在纸中,需要进行纸保护的治疗,例如间接封闭纸.
- 传统材料往往表现出有限的重矿化和牙产生的潜力.
- 需要一种新的生物活性物质来增强牙修复和肉质保护.
研究的目的:
- 开发和评估一种酸树脂复合物 (RC),用于增强牙重矿化.
- 评估RC刺激修复性牙生成及其免疫调节作用的能力.
- 调查RC作为间接纸封盖的先进材料的潜力.
主要方法:
- 制备了酸树脂复合物 (RC),并测量了其在口服条件下的离子释放.
- 实验室研究评估了RC提取物对牙髓干细胞和中性粒细胞的影响.
- 在大鼠模型中评估了脱矿牙的重矿化和修复性牙形成.
主要成果:
- 该RC稳步释放了,和离子.
- 在牙髓干细胞中,RC提取物促进了矿物结节的形成和上调造基因 (DSPP,DMP1,MEPE).
- 在大鼠模型中,与iRoot BP相比,RC显示出显著的牙重矿化和更强大的修复性牙形成.
结论:
- 新的RC表现出有效的重矿化,牙生成和免疫调节性质.
- 这种生物活性物质对先进的牙复矿化疗法具有很大的潜力.
- 该RC提供了一个有前途的替代间接纸封闭,可能避免根管治疗.
更多相关视频
08:26Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
Published on: July 10, 2014
07:42Quasistatic Mechanical Testing for Computer-Aided Design and Manufacturing Occlusal Veneers Cemented to Milled Dentin Analog Material
Published on: December 20, 2024
相关概念视频
Bone as Supporting Connective Tissue
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
The Bone Matrix
Essential Minerals for Bone Health
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Aggregate Cement Ratio
Superplasticizers
Bioplastics
