化学表征,抗氧化剂和分子对接研究Ajwa纸和种子协奏提取物作为潜在的抗血解剂
Muhammad Azam1, Aisha Sana2, Rubeena Saleem3
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, Karachi-Pakistan.
Pakistan journal of pharmaceutical sciences
|August 5, 2025
概括
阿贾瓦日果和种子提取物显示出强大的抗氧化剂和膜保护作用. 这些结合的天然产品显示出在营养药应用中使用的巨大潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 植物化学 植物化学
- 营养保健品 营养保健品
背景情况:
- 生物活性天然产品可以表现出协同作用的治疗效果.
- 氏甲状植物种类 (Phoenix dactylifera var.) 是一个类型. 阿杰瓦 (Ajwa日) 和其副产品含有丰富的植物营养素.
- 对于传统的单一化合物方法来说,研究结合的天然产品是具有挑战性的.
研究的目的:
- 为了研究AJWA杂质和种子 (APS) 提取物的植物化学特征.
- 评估APS提取物的抗氧化和膜保护活性.
- 探索APS的潜在营养应用.
主要方法:
- 气色谱-质谱 (GC-MS) 和核磁共振 (NMR) 用于植物化学分析.
- 活体和体外试验包括氧化血解抑制,DPPH基因清除,ABTS基因离子脱色和β-胡卜素漂白试验.
- 分子对接研究,以评估与红细胞 (RBC) 蛋白质的结合亲和力.
主要成果:
- GC-MS在APS中确定了73种化合物,其中二伊索布甲酸盐,甲基棕酸盐和甲基酸盐是主要成分.
- 总的和黄酸盐含量被量化.
- 在DPPH,ABTS和β-胡卜素漂白试验中,APS提取物显著抑制了氧化血解 (>90%) 和强烈的抗氧化活性.
- 对接研究支持了抗氧化剂和膜保护机制.
结论:
- 结合Ajwa纸和种子提取物具有显著的抗氧化和膜保护性质.
- 鉴定出的植物化学物质有助于观察到的治疗效果.
- APS提取物显示出相当大的发展前景,作为一种营养成分.
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