JMJD8 乳腺癌过度表达:对诊断,预后和免疫微环境相互作用的影响
Chenlei Zhu1, Tianyi Xi1, Guorong Yang1
1Department of General Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.
Frontiers in oncology
|August 5, 2025
概括
乳腺癌中JMJD8的水平升高,导致预后恶化和免疫抑制. 淘汰JMJD8可以增强抗瘤免疫力,并抑制癌细胞的增殖,这表明JMJD8是预后生物标志物.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 乳腺癌的诊断和治疗仍然具有挑战性,因为检测迟到,治疗选择有限.
- 目前尚不清楚JMJD8在乳腺癌中的作用及其对瘤微环境的影响.
- 需要对潜在的乳腺癌生物标志物的系统评估.
研究的目的:
- 研究JMJD8表达与乳腺癌预后之间的关联.
- 探索JMJD8与乳腺癌中的免疫透微环境之间的关系.
- 评估JMJD8作为乳腺癌潜在的预后生物标志物.
主要方法:
- 利用了癌症基因组图谱 (TCGA) 对乳腺癌 (BRCA) 患者的数据.
- 评估JMJD8表达与临床特征的相关性,使用Wilcoxon签名等级测试和后勤回归.
- 通过卡普兰-梅尔和考克斯回归分析了整体生存影响.
- 创建了JMJD8淘汰赛BRCA细胞系,用于体外和体外关于增殖和抗瘤免疫力的研究.
主要成果:
- 与正常组织相比,BRCA组织中的JMJD8表达显著升高.
- 高JMJD8表达与晚期病理阶段相关,并预测整体存活率较低.
- 绝杀JMJD8通过激活cGAS-STING通路,促进树突细胞成熟,并抑制BRCA细胞增殖来增强抗瘤免疫力.
- JMJD8表达与M2巨细胞透具有积极的相关性,这表明它在创造免疫抑制瘤微环境方面发挥了作用.
结论:
- 乳腺癌中JMJD8表达升高与疾病进展和免疫细胞透的改变有关.
- JMJD8可以作为预后生物标志物,表明免疫抑制瘤特征.
- 准JMJD8可能会导致乳腺癌管理的新型治疗策略.
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