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慢性乙型肝炎的定量HBsAg水平的临床和组织病理相关性

Turgay Yılmaz¹, Erdoğan Özdemir¹, Deccane Düzenci²

¹Department of Internal Medicine, Fethi Sekin City Hospital, Elazig, Turkey.

International journal of hepatology

|August 5, 2025

概括

这项研究发现,尽管HBVDNA高,但HBeAg阳性慢性乙型肝炎患者的定量HBsAg水平较低. 定量HBsAg不是慢性乙型肝炎肝纤维化的可靠标志物.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
免疫学免疫学免疫学

背景情况:

慢性乙型肝炎 (CHB) 是一个重要的全球健康问题.
了解CHB的不同临床形式对于有效管理至关重要.
定量乙肝表面抗原 (qHBsAg) 是一个潜在的生物标志物,但其作用需要进一步澄清.

研究的目的:

为了比较不同CHB临床形式的人口,实验室,病毒学和病理学特征.
调查qHBsAg水平与这些参数之间的关系.
评估qHBsAg对于肝纤维化和死炎的诊断价值.

主要方法:

对307名患有CHB (HBeAg阳性和HBeAg阴性) 和HBeAg阴性慢性HBV感染的患者进行前性研究.
收集人口统计数据,肝功能测试 (ALT,AST,GGT,ALP,胆红素),HBV DNA和qHBsAg水平.
111名患者的肝脏活检以评估组织学活性指数 (HAI) 和纤维化阶段 (ISHAK评分).

主要成果:

与HBeAg阴性慢性HBV感染相比,CHB患者的ALT和HBVDNA水平显著更高.
HBeAg阳性CHB患者的qHBsAg水平明显低于HBeAg阴性CHB患者.
在qHBsAg水平和纤维化严重程度或死炎活性之间没有发现显著的关联;ROC分析表明先进纤维化的诊断价值有限.

结论:

截然不同的CHB临床形式表现出可变的实验室和病毒学特征.
HBeAg阳性CHB的特点是HBVDNA高,qHBsAg水平低.
qHBsAg作为评估肝纤维化或CHB活动的独立标志物具有有限的实用性,需要对患者评估采取全面的方法.

关键词:

慢性乙型肝炎慢性乙型肝炎组织病理学组织病理学这是一个定量的HBsAgAg.

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