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Updated: Sep 12, 2025

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精神疾病中口腔微生物组合的改变:系统性审查和元分析

Dingxin Cao¹, Jun Yang¹, Yiwen He¹

¹Department of Endodontics, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.

Journal of oral microbiology

|August 5, 2025

概括

口腔微生物组在精神障碍中显示出改变的多样性,与精神分裂症和自闭症等疾病相关的特定微生物变化. 这些发现表明口腔微生物组.

科学领域:

微生物组研究的研究.
神经科学是一个神经科学.
心理健康心理健康

背景情况:

肠-大脑轴与精神障碍有关,但口腔微生物组的作用还没有得到充分研究.
口腔微生物签名可能会提供对精神障碍病理生理学的见解.
研究口腔微生物组可能会导致新的诊断生物标志物和治疗方法.

研究的目的:

在六种精神疾病中系统地审查和元分析口腔微生物群的变化.
综合病例控制研究的数据,以比较患者和对照组之间的口腔微生物多样性.

主要方法:

来自PubMed,Embase和Cochrane图书馆的20项病例控制研究的系统审查和元分析.
提取相对微生物丰富度和β多样性指数.
对α多样性的随机效应元分析,以比较患者和对照组.

主要成果:

与对照组相比,在患者中观察到显著更高的辛普森指数 (SMD = 0.42).
贝塔多样性在精神分裂症 (SZ) 和严重抑郁症 (MDD) 中显著不同.
具体的微生物变化包括自闭症谱系障碍 (ASD) 中的*Rothia*丰富,SZ中产生H2S的属,MDD中减少的*Solobacterium*和*Leptotrichia*.

结论:

口腔微生物群的多样性在各种精神障碍中发生变化.
与疾病相关的微生物变化表明口腔微生物组在心理健康中的潜在作用.
针对口腔微生物群的诊断和治疗应用需要进一步的研究.

关键词:

口腔的微生物群.阿尔法多样性的多样性自闭症谱系障碍自闭症谱系障碍精神障碍精神障碍精神障碍微生物组的调节失调唾液中的生物标志物

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