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2型糖尿病患者SGLT-2抑制剂对肝功能和夜的差异影响:一项随机对照试验
Tetsuya Kawahara1,2, Mikio Toda1, Maiko Kanagawa3
1Division of Endocrinology and Metabolism, Shinkomonji Hospital, Kitakyushu, 800-0057, Japan.
概括
-葡萄糖携带载体-2 抑制剂 (SGLT-2is) 在患有MASLD的2型糖尿病患者中改善肝功能. 与其他SGLT-2is相比,tofogliflozin显示出更好的夜病概况,这表明潜在的患者特异性益处.
科学领域:
- 内分泌学和新陈代谢学
- 肝病学 肝病学是一种肝病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是2型糖尿病患者日益关注的问题.
- -葡萄糖携带载体-2 抑制剂 (SGLT-2is) 以其降血糖效应和对心血管和结局的潜在益处而闻名.
- 在患有2型糖尿病和MASLD的患者中,SGLT-2对肝功能和夜的影响需要进一步调查.
研究的目的:
- 为了确定SGLT-2抑制剂是否可以改善2型糖尿病和MASLD患者的肝功能,作为一种类效应.
- 评估三种SGLT-2抑制剂 (托法格利夫洛辛,达帕格利夫洛辛,恩帕格利夫洛辛) 对夜频率的影响.
- 评估二次结果,包括血糖控制,体重和脂质概况.
主要方法:
- 一项随机试验,涉及135名2型糖尿病和MASLD患者.
- 参与者接受了托福利弗洛辛 (每天20毫克),达帕格利弗洛辛 (每天5毫克) 或恩帕格利弗洛辛 (每天10毫克) 治疗7个月.
- 主要结局包括肝功能标志物,纤维化指数和夜尿频率的变化;次要结局是代谢参数.
主要成果:
- 这三种SGLT-2抑制剂都显著改善了肝功能标志物,而没有跨组差异.
- 晚的频率最初增加了empagliflozin和dapagliflozin,但没有tofogliflozin.
- 在所有治疗组中,血糖控制,体重和脂质概况均有相似的改善.
结论:
- SGLT-2 抑制剂在改善2型糖尿病和MASLD患者的肝功能方面表现出一种类效应.
- 与empagliflozin和dapagliflozin相比,tofogliflozin在夜方面表现出更有利的概况,可能是由于其半衰期更短.
- 托福格利弗洛辛可能是2型糖尿病和MASLD患有夜尿障碍风险的患者的首选SGLT-2抑制剂.
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