在患有阻塞性睡眠呼吸暂停的吸烟患者中,循环增长和上呼吸道缩性增加
Liang-Wen Hang1,2, Eysteinn Finnsson3, Jón S Ágústsson3
1College of Medicine, China Medical University, Taichung, Taiwan.
ERJ open research
|August 5, 2025
概括
吸烟加剧阻塞性睡眠呼吸暂停 (OSA),增加上呼吸道的折叠性和循环增长. 这些对OSA内型的负面影响在戒烟后可能是可逆的.
科学领域:
- 睡眠医学 睡眠医学
- 呼吸系统医学 呼吸系统医学
- 心血管生理学心血管生理学
背景情况:
- 吸烟是阻塞性睡眠呼吸暂停 (OSA) 的已知危险因素,但潜在的病理机制尚未完全理解.
- 在OSA患者中研究与吸烟相关的内型特征对于了解疾病机制至关重要.
研究的目的:
- 为了探索阻塞性睡眠呼吸暂停 (OSA) 的特定内型特征,目前和前吸烟者.
- 阐明吸烟与OSA严重程度和特征相关的病理机制.
主要方法:
- 从980名中度至重度OSA (呼吸暂停-呼吸暂停指数≥15小时−1) 患者中收集了多睡眠记录数据.
- 估计内型特征,包括唤醒值,可折叠性,循环增益,循环延迟和透气反应,使用多睡眠信号.
- 多变量线性回归分析,以评估吸烟状态和内型特征之间的关联.
主要成果:
- 当前吸烟者在非快速眼动 (NREM) 睡眠期间表现出更高的呼吸暂停-呼吸暂停指数 (AHI),更高的唤醒值,更高的循环增益和减少循环延迟.
- 在快速眼动 (REM) 睡眠期间,当前吸烟者表现出更高的唤醒值,更高的循环增益和减少延迟,以及较低的通风.
- 与非吸烟者相比,前吸烟者在REM睡眠期间表现出较低的上呼吸道补偿和下通风,而非吸烟者则表现出较低的上呼吸道补偿和下通风.
结论:
- 在OSA患者中,吸烟与上呼吸道缩性和循环增长的增加显著相关.
- 这些吸烟引起的OSA内型变化表明疾病恶化的潜在机制.
- 这些发现表明,戒烟可能会导致这些病理特征的可逆改善.
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