在喘治疗和怀孕期间恶化后,婴儿呼吸系统的结果
Bronwyn K Brew1,2, Peter G Gibson1,2,3, Adam M Collison1,2
1School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.
ERJ open research
|August 5, 2025
概括
怀孕期间母亲喘恶化会增加婴儿患支气管炎和喘息的风险. 改善喘管理和在怀孕期间使用吸入性皮质类固醇 (ICS) 并没有显著减少这些婴儿呼吸系统结果.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 肺部病理学 肺部病理学
背景情况:
- 怀孕期间母亲的喘管理可能会影响婴儿的呼吸系统健康.
- 婴儿时期的复发性支气管炎和喘息是与母亲喘控制相关的潜在结果.
研究的目的:
- 评估由炎症引导的喘管理干预,吸入性皮质类固醇 (ICS) 使用,以及怀孕期间母亲喘恶化对婴儿支气管炎和喘息结果的影响.
主要方法:
- 进行了一项随机对照试验 (RCT) 的二次分析和观察性队列分析.
- 孕妇 (12-23周怀孕) 被随机分配到由炎症引导的喘管理或常规护理.
- 在6个月和12个月时收集婴儿呼吸系统信息,并使用逻辑回归分析相关性.
主要成果:
- 在怀孕期间以炎症为导向的喘治疗与婴儿支气管炎或喘息不相关.
- 怀孕期间母亲吸入皮质类固醇 (ICS) 的使用与婴儿呼吸系统结果没有关联.
- 孕妇在怀孕期间的喘恶化与婴儿支气管炎,和喘息发作的增加显著相关.
结论:
- 虽然指导性喘管理和怀孕期间ICS的使用并没有减少婴儿的呼吸问题,但母亲喘恶化代表了一个重要的风险因素.
- 需要进行进一步的研究,以制定减少怀孕期间母亲喘恶化的策略,以改善婴儿呼吸系统健康.
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