在科学文献中使用的反复植入失败定义的可变性和影响:系统性审查
Jessica K Lu1, Yin Jun Law1, Ning Zhang1
1School of Women's and Children's Health, UNSW Medicine and Health, University of New South Wales, Sydney, Randwick, Australia.
Human reproduction open
|August 5, 2025
概括
复发性植入失败 (RIF) 的定义在研究中差异很大,大多数研究都不符合ESHRE标准. 标准化RIF定义对于可靠地解释研究结果和推进RIF研究至关重要.
科学领域:
- 生殖医学 生殖医学
- 不孕症研究 不孕症研究
- 辅助生殖技术 (ART) 是一种辅助生殖技术.
背景情况:
- 复发性植入失败 (RIF) 是ART失败的重要原因之一,也是研究的重点.
- 现有的文献缺乏对RIF的一致的定义,使研究解释和临床应用复杂化.
研究的目的:
- 在已发表的文献中定义反复植入失败 (RIF).
- 评估现有的RIF定义与2023年欧洲人类生殖和胚胎学会 (ESHRE) 标准的预后一致性.
主要方法:
- 在主要数据库 (EMBASE,PubMed,CENTRAL,Scopus,Web of Science) 进行系统的文献搜索,截至2024年6月.
- 从748个符合条件的文章中手动提取RIF定义和研究特征.
- 对RIF定义的分析与预先确定的指标进行比较,并与ESHRE标准进行比较.
主要成果:
- 在748项研究中,发现了500多个独特的RIF定义.
- 共同的决定性因素包括胚胎质量,转移事件数量和转移的累积胚胎.
- 大多数已识别的RIF定义不符合ESHRE诊断值,这表明研究中的RIF患者可能被错误分类.
结论:
- 在已发表的研究中,RIF定义存在显著的变化和差异.
- 很少有研究符合ESHRE RIF诊断值,质疑研究群体的真正RIF状态.
- 标准化的RIF定义对于准确解释和未来RIF研究的临床适用性至关重要.
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