致癌性CMTM6驱动M2a巨细胞的形成,并促进子宫癌的进展

Bo Yin1, Chun Chen2, Baoyou Huang1,3

  • 1Department of Gynecology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

PubMed
概括

外体CMTM6通过促进M2a巨细胞两极分化和激活mTOR通路来驱动子宫癌中的免疫抑制. 这种CMTM6/CD206/CCL2轴恶化了预后,并为宫癌免疫治疗提供了潜在的治疗标.

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