精神分裂症相关的便菌群变化和系统性免疫功能障碍:中国老年患者的队列研究
Zongxin Ling1, Yiwen Cheng1, Xia Liu2
1Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Frontiers in immunology
|August 5, 2025
概括
肠道菌群变化,包括增加的真菌多样性和特定的真菌丰富物,与老年精神分裂症患者的免疫功能障碍有关. 这些变化可能成为诊断精神分裂症的潜在非侵入性生物标志物.
科学领域:
- 菌类学 菌类学是指菌类学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症 (SZ) 的病因涉及遗传和环境因素.
- 肠道微生物组失生症与SZ有关,但真菌成分 (菌群) 未得到充分研究.
- 老年SZ患者代表了菌生物研究的独特人群.
研究的目的:
- 为了研究与健康对照组 (HCs) 相比,老年SZ患者的肠道菌群组成.
- 评估肠道菌群和宿主免疫反应在SZ.之间的关系.
- 为了确定潜在的真菌生物标志物用于SZ诊断.
主要方法:
- 内部转录间隔器1 (ITS1) 片测序用于肠道菌群分析.
- 多重免疫试验用于评估宿主系统性免疫反应.
- 接收器运行特征 (ROC) 分析用于生物标志物潜在评估.
主要成果:
- SZ患者表现出增加的真菌α多样性和丰富性,与改变的β多样性.
- 在SZ中观察到巴西迪奥米科塔/阿斯科米科塔比率升高以及Candida,Aspergillus和Saccharomyces的丰富.
- 特定的真菌 (S. cerevisiae,P. lilacinum) 与免疫功能障碍相关,可以区分SZ患者和HC患者.
结论:
- 肠道菌群失生症在老年SZ患者中很明显,其特点是菌的组成和多样性发生变化.
- 菌变化与系统性免疫功能障碍有关,这表明它在SZ病变发生过程中发挥了作用.
- 特定的肠道真菌显示出作为SZ诊断的非侵入性生物标志物的潜力,并可能提供治疗点.
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