雌激素受体和温度独立地影响红耳滑的性别决定
Xifeng Wang1, Zihan Ding1,2, Pengfei Wu1
1Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Frontiers in endocrinology
|August 5, 2025
概括
雌激素通过雌激素受体 (ESR) 触发温度依赖性性别决定 (TSD) 爬行动物的雌激素发育. 这种机制在男性产生温度时至关重要,但在女性产生温度时不至关重要.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 温度依赖性性别决定 (TSD) 在爬行动物中很常见,雌激素影响女性的发育.
- 在TSD爬行动物中,精确的分子途径将雌激素与卵巢分化联系在一起,尚未完全理解.
研究的目的:
- 研究雌激素受体 (ESR) 在调解雌激素对TSD爬行动物的卵巢分化影响中的作用.
- 为了阐明雌激素诱导的红耳滑的性别逆转的分子机制.
主要方法:
- 在男性生产温度 (MPT) 和女性生产温度 (FPT) 上给红耳滑胚胎注射17β-雌激醇 (E2),ESR激动剂和ESR抗体.
- 分析淋巴体形态和关键性决定基因的表达 (Cyp19a1,Foxl2,Amh,Dmrt1).
主要成果:
- 在MPT中,E2或ESR激动剂诱导了女性淋巴体特征,改变了与女性化一致的基因表达模式.
- 在MPT中E2诱导的男性到女性的性别逆转在ESR对抗剂中是可逆的.
- ESR对抗性没有影响FPT的卵巢分化,这表明涉及其他途径.
结论:
- 雌激素利用ESR来调节性别特异性基因表达,在TSD爬行动物的MPT中驱动卵巢分化.
- 在FPT中,ESR对于卵巢发育并不重要,这表明在自然高温条件下存在替代性女性化途径.
相关概念视频
Background and Environment Affect Phenotype
6.7K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.7K
Thermoregulation
1.3K
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
1.3K
The Ratio of X Chromosome to Autosomes
8.8K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
8.8K
Factors Affecting Body Temperature
6.6K
As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may include:
Factors may include:
6.6K
Thermosensation
31.8K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
31.8K


