在南亚临床环境中,心肌梗塞后心脏病患者中抑郁症和药物坚持之间的关联
Samraiz Nafees1, Niamat Ali2,3, Abali Wandala4,5
1Internal Medicine, York and Scarborough Teaching Hospitals NHS Foundation Trust, Scarborough, GBR.
Cureus
|August 5, 2025
概括
在心肌梗塞后的患者中,较高的抑郁症状出乎意料地与更好的药物坚持有关. 这表明心理健康支持和坚持策略对于心脏恢复至关重要,特别是在南亚的环境中.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 药物坚持对于心肌梗塞 (MI) 后恢复至关重要.
- 在心脏病发作后,抑郁症很常见,并且可能会损害药物坚持.
- 南亚的文化因素可能会影响抑郁症与坚持的关系.
研究的目的:
- 为了调查后心脏病患者抑郁症和药物坚持之间的联系.
- 在南亚临床环境 (巴基斯坦伊斯兰堡) 中探索这种关系.
主要方法:
- 对385名心脏病后门诊患者的横截面研究.
- 使用患者健康问卷-9 (PHQ-9) 评估抑郁症.
- 用莫里斯基药物坚持度表 (MMAS-8) 量化药物坚持度.
- 采用描述性统计学,正常性测试,斯皮尔曼相关性,克鲁斯卡尔-瓦利斯,奇平方和线性回归.
主要成果:
- 在PHQ-9和MMAS-8得分之间发现了一个弱而显著的正相关性 (r=0.124,p<0.05).
- 更高的抑郁症状预测了更大的药物坚持 (B=0.064,p=0.002).
- 抑郁症随着心脏病发作和更高的药物负担的时间而恶化;每天服用3-5种药物时,坚持是最高的.
- 坚持和痛苦率因治疗类型而异,血管造形术患者表现出最好的坚持.
结论:
- 与之前的研究相反,这项研究发现后心脏病患者的抑郁症状和药物坚持之间存在积极的相关性.
- 在这种文化背景下,抑郁症状可能与增加的健康意识或计划的护理使用并存.
- 综合心理健康查和坚持支持是建议的后MI护理,考虑到并发症和治疗的复杂性.
相关概念视频
01:28Acute Coronary Syndrome IV: Interprofessional Care
28
IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
28
01:23Antidepressant Drugs: MAOIs and Other Agents
353
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
353
01:28Drug Therapy
100
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
100
01:25Antidepressant Drugs: Overview
757
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
757
01:27Coronary Artery Disease V: Interprofessional Care
33
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
33
01:18Depression: Overview
340
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
340