同时治疗与三重治疗在消灭Helicobacter pylori感染方面的有效性:一项回顾性研究
Muhammad Umair Mazhar1, Hafiz Muhammad Ahmad Anees2, Samana Mukhtar2
1Stroke Medicine, University Hospital Coventry and Warwickshire NHS Trust, Coventry, GBR.
Cureus
|August 5, 2025
概括
同时治疗 (CT) 显示出更高的疗效比标准的三重治疗 (TT) 根除Helicobacter pylori感染. 较年轻的患者和较短的症状持续时间预测CT的成功,为资源有限的环境提供了洞察力.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 在全球范围内,Helicobacter pylori感染对健康和经济造成了重大负担.
- 增加抗生素耐药性损害了标准三重疗法 (TT) 的有效性.
- 在像巴基斯坦这样的资源有限的环境中,对H. pylori治疗方案的比较研究有限.
研究的目的:
- 为了比较同时治疗 (CT) 与标准三重治疗 (TT) 的疗效,用于H. pylori根除.
- 在不同的治疗方案中确定成功根除H. pylori的预测因素.
主要方法:
- 在巴基斯坦对296名H. pylori感染患者进行了12个月的回顾性研究.
- 患者接受了CT (以斯莫普拉,阿莫西西林,克拉里素,美特罗尼达) 或TT (以斯莫普拉,阿莫西西林,克拉里素).
- 通过尿素呼吸试验证实了H. pylori的根除;使用t测试,奇平方和后勤回归 (p<0.05显著) 分析的数据.
主要成果:
- 总体而言,H. pylori的根除率为82.09%.
- 与TT (72.29%) (p=0.008) 相比,CT实现了显著更高的根除率 (91.90%) .
- 在CT组中,年龄较小和症状持续时间较短预测了成功根除.
结论:
- 同时治疗 (CT) 对H. pylori根除的标准三重治疗 (TT) 显示出更高的疗效.
- 年轻的年龄 (<45岁) 和症状持续时间 (<6个月) 是成功CT结果的关键预测因素.
- 研究结果支持CT作为资源有限的环境中首选的治疗方案,并强调需要进一步研究最佳的H. pylori治疗方案.
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