药物遗传测试在美国的流行程度
Annika M Czizik1, Hannah Burkett1, Joshua C Black1
1Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, Denver and.
Pharmacogenetics and genomics
|August 5, 2025
概括
药物遗传学 (PGx) 测试在美国很少,只有6.6%的成年人接受过该程序. 大多数成年人 (7900万) 希望进行PGx测试,这表明目前的实施和认识存在重大差距.
科学领域:
- 药物基因组学 药物基因组学
- 临床药房 临床药房
- 公共卫生 公共卫生
背景情况:
- 药物遗传学 (PGx) 测试,分析影响药物反应的遗传变异,具有潜在的临床实用性,但其在美国的人口水平的吸收尚未确立.
- 了解PGx测试的普及率以及美国成年人群中对其的渴望对于为医疗保健政策和实施策略提供信息至关重要.
研究的目的:
- 确定美国成年人接受药物遗传学 (PGx) 测试的患病率.
- 评估美国成年人中希望接受PGx测试的比例.
- 为了确定与拥有或想要PGx测试相关的健康特征.
主要方法:
- 一项针对美国成年人的全国代表性在线调查 (N=29,146) 是使用处方药非医疗用途计划进行的.
- 使用加权后勤回归分析来检查与PGx测试吸收和测试愿望相关的因素.
- 调查数据代表了大约2.6亿美国成年人.
主要成果:
- 美国成年人曾经接受过PGx测试的患病率为6.6% (95%CI:6.2-7.0).
- 很大一部分32.2% (估计有7900万成年人) 表示希望进行PGx测试.
- 与拥有或想要进行PGx测试相关的因素包括女性,高等教育,学生身份,军事隶属,药物使用和精神健康障碍的存在.
结论:
- 药物遗传学 (PGx) 测试在美国成年人群中仍然很低.
- 对于PGx测试存在大量未满足的需求,数以百万计的人希望接受该程序.
- 弥合关于PGx测试益处的知识差距对于加强其在临床实践中的实施至关重要.
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