过度表达HOX11基因与急性B型淋巴细胞白血病的复发有关
Mingyan Zhong1, Changxin Yin2, Yulian Wang3
1Department of Paediatric Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, China.
British journal of haematology
|August 5, 2025
概括
荷莫盒子11 (HOX11) 基因过度表达与急性B细胞淋巴细胞白血病 (B-ALL) 的复发率更高有关. 这一发现突出了HOX11作为B-ALL患者疾病进展的潜在独立风险因素.
科学领域:
- 血液学 血液学 血液学
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 急性B细胞淋巴细胞白血病 (B-ALL) 是一种异质的血液恶性瘤.
- 识别与耐药性疾病和复发相关的遗传因素对于改善患者的治疗结果至关重要.
研究的目的:
- 调查Homeo Box 11 (HOX11) 基因过度表达和耐火性B-ALL之间的关联.
- 分析HOX11表达与B-ALL.的临床特征,遗传变化和无进展生存 (PFS) 的相关性.
主要方法:
- 实时定量聚合酶链反应 (RQ-PCR) 用于评估来自209名B-ALL患者的骨髓样本中的HOX11表达.
- 与HOX11表达水平一起,分析了临床数据和遗传改变.
- 进行了后勤回归和考克斯回归分析,以评估HOX11对复发和PFS的影响.
主要成果:
- 在12.4%的B-ALL患者中检测到HOX11过度表达,复发率更高 (26例中10例).
- 过度表达HOX11与TP53同时发生的变化 (23.07%与8.7%,p<0.05),较低的白细胞计数和更高的复发率 (p<0.05) 相关.
- 过度表达HOX11和KMT2A::AFF1融合是疾病复发和减少PFS的独立风险因素 (p=0.041).
结论:
- 过度表达HOX11基因与耐火性B-ALL和更高的疾病复发率显著相关.
- 在B-ALL患者中,HOX11作为无进展生存的独立预后标记.
- 这些发现为B-ALL折射性和复发背后的分子机制提供了新的见解.
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