产后的抗生素暴露由于母体B型链球菌与儿童喘有关
Eyal Kristal1,2, Itamar Ben Shitrit1,3, Yoram Faitelson2
1Saban children's Hospital, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er Sheva, Israel.
概括
婴儿早期接触抗生素,即使没有感染,也会增加儿童喘风险. 这项研究强调了在评估喘发展时,需要考虑对孕产妇的抗生素使用.
科学领域:
- 儿科 儿科 儿科
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 早期的抗生素暴露是儿童喘的已知危险因素.
- 以前的研究可能会被抗生素使用的指示 (例如,呼吸道感染) 混.
- 这项研究旨在分离出母性原因给非感染婴儿的抗生素的作用.
研究的目的:
- 评估产后抗生素治疗对儿童喘风险的独特贡献.
- 为了减轻先前研究中婴儿感染的混偏差.
- 调查非传染性适用抗生素使用与喘发展之间的关联.
主要方法:
- 使用电子病历进行的回顾性队列研究 (2006-2018).
- 鉴定出患有阳性B组链球菌 (GBS) 培养的母亲出生的健康婴儿.
- 排除了有呼吸道症状或阳性培养的婴儿;用于分析的准森回归和倾向性得分匹配.
主要成果:
- 产后抗生素暴露与喘风险增加有关 (aRR=1.3,P=.017),通过倾向模型 (aRR=1.49,P=.005) 验证.
- 抗生素治疗也与短期β-agonist使用的增加有关 (aRR=1.13,P=.072) 和过敏性鼻炎诊断 (aRR=3.00,P=.003).
- 在控制混因子和排除感染的婴儿后,这种关联仍然存在.
结论:
- 产后抗生素治疗母亲的GBS,独立于婴儿感染,与更高的儿童喘风险有关.
- 研究结果表明,某些抗生素暴露对喘发展有直接影响.
- 强调了明智使用抗生素的重要性,即使对于孕产妇的指示.
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