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从PGCCs开始的女儿细胞及其在口腔状细胞癌中的临床病理学意义

Shanshan Zhuo¹, Chao Jing², Xiaonan Liu³

¹Department of Ear Nose and Throat, Tianjin Hospital, Tianjin, China.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

|August 5, 2025

概括

多倍体巨型癌细胞 (PGCCs) 存在于口腔状细胞癌 (OSCC) 中,并与较差的存活率有关. 这些细胞由低氧诱导,增强OSCC的增殖,耐药性和通过干细胞和EMT表型的迁移.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
细胞生物学细胞生物学

背景情况:

多倍体巨型癌细胞 (PGCC) 涉及到各种癌症,但它们在口腔状细胞癌 (OSCC) 中的作用尚不清楚.
由于与瘤进展有关,PGCCs是潜在的治疗点.

研究的目的:

在OSCC组织中调查PGCC的存在和数量.
评估PGCC与临床病理因素和患者存活率的关联.
检查PGCC形成机制及其对OSCC扩散,耐药性和迁移的影响.

主要方法:

在76个OSCC患者组织中评估了PGCC计数,与临床结果相关.
在OSCCUM1细胞中诱导PGCC形成,使用CoCl2.
分析了HIF-1α,SOX-2,E-cadherin和N-cadherin表达的改变,以及扩散,耐药性和迁移测试.

主要成果:

较高的PGCC计数 (>3/HP) 与晚期的临床阶段,较差的组织学等级和减少的化疗反应相关.
患有更多PGCC的患者的整体和无病生存率明显降低.
诱导的PGCCs显示了上调的SOX-2,增加的HIF-1α,SOX-2,N-cadherin和降低的E-cadherin,以及增强的增殖,化学抵抗和迁移.

结论:

缺氧可以通过促进PGCC形成来推动OSCC的进展.
在PGCC中,表现出干性和表皮-介质细胞过渡 (EMT) 现型.
PGCCs有助于增加OSCC的扩散,化学抵抗和迁移.

关键词:

在 CoCl2Cl2 中.口腔状癌细胞的细胞.病理学的病理学多化巨型癌细胞.预后预后预后

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