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来自瘤细胞的FGF-2促进淋巴细胞形成,作为OSCC的预后标志物

Jia Kang¹, Aoming Cheng¹, Guanzheng Chen¹

¹Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

|August 5, 2025

概括

纤维细胞生长因子-2 (FGF-2) 驱动了口腔状细胞癌 (OSCC) 的淋巴血管生成,创造了一个寒冷的瘤微环境. 向FGF-2/FGFR1可以通过增强CD8+T细胞透来改善OSCC预后.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症生物学癌症生物学

背景情况:

口腔状细胞癌 (OSCC) 的特点是"冷"的瘤微环境,与瘤相关的淋巴血管影响免疫细胞运输和预后.
瘤诱导的淋巴血管生成在CD8+T细胞透和OSCC的瘤免疫微环境中的确切作用尚不清楚.

研究的目的:

调查OSCC中淋巴血管生成因子的预后意义.
阐明纤维细胞生长因子-2 (FGF-2) 对淋巴血管生成,CD8+T细胞透和OSCC瘤微环境的影响.

主要方法:

对癌症基因组图谱数据集和组织样本进行分析,以确定淋巴细胞形成因子的预后意义,重点关注FGF-2.
在体内和体外实验中评估FGF-2对淋巴内皮细胞和CD8+T细胞透的影响.
使用卡普兰-梅尔和日志等级测试进行生存分析;通过考克斯比例危险模型计算的危险比率.

主要成果:

高水平的FGF-2和增加的周淋巴血管与更糟糕的OSCC预后相关.
来自瘤的FGF-2通过FGFR1/PTEN/AKT通路促进淋巴血管生成,增加CXCL9的分泌,以招募/退出CD8+T细胞.
抑制FGFR1 (PD-166866) 抑制了淋巴血管生成和CXCL9,增强了CD8+ T细胞的透,并抑制了瘤的进展.

结论:

在OSCC中,FGF-2是显著的预后因素,诱导淋巴血管生成并对内CD8+T细胞产生负面影响,从而导致"寒冷"的瘤微环境.
准FGF-2/FGFR1通路是一个潜在的治疗策略,通过调节瘤免疫微环境来改善OSCC预后.

关键词:

CD8+ T 细胞 CD8+ T 细胞纤维细胞生长因子-2 淋巴血管生成 (Lymphangiogenesis) 是一种导致淋巴血管发生的过程.口腔状细胞癌的癌症.预后预后预后

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