儿童心脏移植接受者的单一疗法免疫抑制
Elizabeth L Profita1, Joanne Lee2, Donna Lee2
1Department of Pediatrics (Cardiology), Stanford University, Palo Alto, California, USA.
Pediatric transplantation
|August 5, 2025
概括
接受单一药物免疫抑制 (单一疗法) 的儿科心脏移植患者没有增加排斥风险. 这种方法可能适用于某些经历过度免疫抑制的患者,改善结果.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 移植免疫学 移植免疫学
- 免疫抑制疗法是一种免疫抑制疗法.
背景情况:
- 儿科心脏移植 (HT) 后的标准免疫抑制涉及双重药物.
- 单一药物免疫抑制 (单一疗法) 可能是选择患者的选择.
- 这项研究评估了儿科HT队列中的单疗法.
研究的目的:
- 评估卡尔西纽林抑制剂单疗在儿科心脏移植接受者的疗效和安全性.
- 为了确定单一治疗是否与排斥或不良事件的风险增加有关.
- 确定可能受益于降低免疫抑制的患者子组.
主要方法:
- 儿科心脏移植患者 (2001-2020) 的回顾性审查.
- 对超过一个月接受氨酸抑制剂单疗的患者的分析.
- 评估临床特征,转向单一治疗的原因以及患者的治疗结果.
主要成果:
- 5% (16/318) 的患者转为单一治疗,主要是由于复发性感染,PTLD或中性质衰竭.
- 没有观察到中度或较大的排斥发作或冠状动脉异体移植血管病变.
- 94%的患者在最后一次随访时仍然活着,身体状况良好,87%的患者继续单一治疗.
结论:
- 卡尔西纽林抑制剂单疗可以成为选择儿科心脏移植患者的安全有效策略.
- 在有过度免疫抑制症状的患者中,单一治疗可能是首选.
- 这种方法似乎不会增加拒绝的风险.
相关概念视频
Kidney Transplant I: Introduction
60
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
60
Kidney Transplant III: Nursing Management
82
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
82
Kidney Transplant II: Surgical Procedure
76
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
76
Myocarditis III: Medical Management
16
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
16
Bone Marrow Sampling and Transplants
500
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
500
Tissue Transplantation
520
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
520


