在没有GERD的轻度中度喉膜中抑制酸性:随机对照试验
Amber D Shaffer1, Zainab Balogun1, Allison B J Tobey1
1Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
The Laryngoscope
|August 5, 2025
概括
酸抑制疗法 (AST) 在治疗轻度至中度喉病的婴儿的胃食道逆流 (GER) 和呼吸道症状时,与单独的养修改相比没有额外的益处.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 新生儿科学 新生儿科学
背景情况:
- 喉病是一种常见的先天性疾病,导致婴儿呼吸道阻塞.
- 胃食道逆流 (GER) 可以加剧喉病的症状.
- 经常使用酸抑制疗法 (AST),但其在这种情况下的有效性仍在争论中.
研究的目的:
- 评估酸抑制疗法 (AST) 在诊断为轻度至中度喉病的婴儿中治疗胃食道逆流 (GER) 和呼吸道症状的有效性.
主要方法:
- 一项随机对照试验,涉及轻度至中度喉病的婴儿 (≤6个月).
- 参与者被分配到AST (famotidine + 养修改) 或仅进行养修改.
- 症状严重程度的评估是使用喉气道症状评分 (LASS) 和婴儿胃食道逆流问卷 (I-GERQ-R).
主要成果:
- 在AST组和非AST组之间,在喉气道症状评分 (LASS) 或婴儿胃食道逆流问卷修订 (I-GERQ-R) 评分上没有显著差异.
- 在GER和气道症状的整体改善被观察到,但与AST没有显著的更大.
- 在33%的婴儿中,喉瘤消失了,治疗手臂之间没有显著差异.
结论:
- 与单独的养修改相比,酸抑制疗法 (AST) 对患有轻度至中度喉病的婴儿没有提供额外的益处.
- 可能需要进一步的研究来确定可能受益于AST的特定子组.
- 管理应该专注于保守措施,如养修改.
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