在患有系统性自身免疫性疾病的患者中预防和检测氧化诱导的视网膜病变
1Department of Ophthalmology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Republic of Korea.
Expert opinion on drug safety
|August 5, 2025
概括
长期使用氧化 (HCQ) 可能导致视网膜毒性,风险在5-10年后增加. 定期的眼科查和基于体重的剂量对早期检测和预防视力损失至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 氧化 (HCQ) 是一种疾病修饰药物,用于治疗自身免疫性疾病.
- 长期使用HCQ与不可逆转的视网膜毒性有关.
研究的目的:
- 审查目前对HCQ视网膜病变风险因素和查指南的理解.
- 突出HCQ视网膜病变检测方面的挑战和未来方向.
主要方法:
- 在PubMed和Embase的文献搜索 (2000-2025年).
- 风险因素分析,查建议和检测方式.
主要成果:
- 视网膜病变的风险最初很低,但随着使用的持续时间 (>5-10年) 增加.
- 关键的危险因素包括每日高剂量 (>5毫克/公斤),长期使用,功能障碍和他莫西芬使用.
- AAO建议在5年后使用SD-OCT和视觉场进行基线和年度查.
结论:
- 尽管取得了进展,但在确定安全的HCQ剂量和确保查遵守方面仍然存在挑战.
- 未来的研究重点是成像生物标志物,遗传因素和人工智能,用于早期检测和个性化查,以防止视力丧失.
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