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Updated: Sep 12, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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固有弱协调氧基导向的鲁 ((II) 催化C5功能化2-氨基-4 ((1H) - 单子

Tarun Jangir1, Dhananjay S Nipate1, Vani Dhyani1

  • 1Department of Chemistry, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan 333031, India.

Organic letters
|August 5, 2025
PubMed
概括

这项研究提出了一种新的催化方法,用于对2-arylquinolin-4(1H) -ones的选择性C5功能化. 通过使用各种合伙伴,实现了多种C5替代类的高效合成.

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All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
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