尿细胞学中的诊断挑战:巴黎尿细胞学报告系统的实用见解
Derek B Allison1,2, Christopher J VandenBussche3,4
1Department of Pathology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Cancer cytopathology
|August 5, 2025
概括
尿细胞学有助于诊断高度泌尿腺癌 (HGUC) 和监测复发. 巴黎系统提高了可复制性,但像文物和微妙的异型症这样的挑战需要整合的形态,分子和临床数据来准确诊断.
科学领域:
- 尿路病理学 尿路病理学
- 细胞病理学 细胞病理学
- 在瘤学瘤学.
背景情况:
- 尿细胞学对于诊断高度泌尿腺癌 (HGUC) 和检测复发至关重要.
- 解释性挑战,包括文物和反应性缺陷,可能会阻碍诊断的准确性.
- 巴黎体系标准化了HGUC标准,但错误分类的风险仍然存在,特别是微妙的异型或良性模仿.
研究的目的:
- 评估尿细胞学在HGUC检测中的诊断实用性和挑战.
- 突出巴黎体系在改善诊断可重复性方面的作用.
- 讨论如何整合形态,分子和临床数据以提高准确性.
主要方法:
- 对HGUC的尿细胞学诊断标准和挑战的审查.
- 分析巴黎体系对诊断标准化的影响.
- 探索新兴技术,如分子分析和细胞病理学中的AI.
主要成果:
- 巴黎系统提高了HGUC诊断的可重现性,但并不能消除错误分类的风险.
- 从良性模仿细胞区分HGUC和管理非典型泌尿道细胞仍然是一个重大挑战.
- 低度泌尿瘤很难在空白的标本中检测到.
结论:
- 由巴黎系统指导的尿细胞学仍然对检测HGUC至关重要,重点关注高度病变.
- 准确的诊断需要一个平衡的方法,整合形态专业知识,分子见解和临床数据.
- 人工智能和分子分析的未来进展有望改进尿细胞学在精准医学中的作用.
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