多种kratom产品对使用模式,依赖和毒性的影响
Nina Vadiei1,2,3, Kirk E Evoy1,2,4, Oliver Grundmann5
1The University of Texas at Austin College of Pharmacy, Austin, TX, USA.
Current psychiatry reports
|August 5, 2025
概括
含有缩或分离的类化合物的新克拉产品对健康构成重大风险. 这些强大的衍生品,与传统的 kratom 叶不同,具有更高的毒性和依赖潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 拉特产品在美国已经有十多年了,最初是用拉特叶制成的粉末,囊或药片.
- 最近,包括提取物,缩物和分离物在内的各种 kratom 产品已在市场上销售.
- 本综述侧重于缩或分离的克拉衍生类产品及其相关风险.
研究的目的:
- 审查含有缩或分离的克拉衍生物类化合物的产品的不同症状呈现.
- 突出这些产品可能对消费者构成的重大风险.
- 为了解决强效的克拉衍生物日益严重的公共卫生问题.
主要方法:
- 对现有临床和临床前数据的文献综述.
- 对产品成分和类化合物含量的分析.
- 检查报告的不良事件和症状表现.
主要成果:
- 缩的 kratom 提取物可以具有高达 60% 的类化合物含量,而天然叶子的含量为 2-5%.
- 产品与隔离的7-基米特拉基因和米特拉基因伪素是强大的阿片类药物激动剂,不自然存在于 kratom 叶.
- 这些新产品带来了更大的毒性风险,药物相互作用和生理依赖,这是由于更高的强度和缺乏监管.
结论:
- 缩和分离的克拉类化物产品对公众健康构成越来越大的关注.
- 关于这些强大的克拉衍生物的安全性和监管,临床研究很少.
- 与传统的全叶 kratom 相比,消费者可能没有意识到这些显著的差异和增加的风险.
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