美国专家Delphi共识关于在用datopotamab deruxtecan治疗的患者中预防和治疗口腔炎
Hope Rugo1, Aditya Bardia2, Debora S Bruno3
1City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
概括
专家共识确定了在接受达托帕马布德鲁克斯泰坎 (Dato-DXd) 的患者中预防和管理口腔炎的指导方针. 这些指导方针旨在改善患者的生活质量和治疗坚持.
科学领域:
- 在瘤学瘤学.
- 临床药理学 临床药理学
- 患者护理 患者护理
背景情况:
- 达托帕马布德鲁克斯泰坎 (Dato-DXd) 是一种抗体-药物联合体,在肺癌和乳腺癌试验中显示出有前途.
- 口腔炎是经常发生的不良事件,影响生活质量和治疗连续性.
- 由于缺乏针对Dato-DXd相关的口腔炎的标准化指南,因此需要专家的共识.
研究的目的:
- 制定专家指导的指导方针,用于预防和管理用Dato-DXd.治疗的患者的口炎.
- 为了解决对这种常见不良事件的标准化护理方案的未满足需求.
- 改善接受Dato-DXd.治疗的肺癌和乳腺癌患者的治疗结果和治疗坚持.
主要方法:
- 一个经过修改的三轮德尔菲过程,涉及15名肺癌和乳腺癌专家.
- 匿名调查,随后进行共识小组会议和 1:1 后续调查.
- 包括在Dato-DXd临床试验和口腔炎管理方面有直接经验的专家.
主要成果:
- 对口腔炎作为影响生活质量的重大不良事件达成共识.
- 在用Dato-DXd治疗的肺癌和乳腺癌患者中发现了类似的口腔炎表现.
- 商定了预防措施 (教育,卫生,预防性口水) 和管理策略 (监测,类固醇口水).
结论:
- 专家的共识为与Dato-DXd相关的口腔炎的预防和管理提供了关键的指导.
- 预计这些指导方针的实施将提高患者的生活质量和治疗遵守性.
- 这些最佳实践支持临床医生等待进一步的临床试验数据.
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