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长期COVID和CKD的关联:来自国家临床队列协作 (N3C) 的发现
A Jerrod Anzalone1, Spencer Krichevsky2, Yun Jae Yoo3
1University of Nebraska Medical Center, Department of Biostatistics, College of Public Health, Omaha, NE.
概括
慢性病 (CKD) 会增加患长期COVID的风险. 即使是轻微的CKD和COVID-19后的新脏问题也与更高的长期COVID率有关,影响了恢复.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在大型患者群体中,慢性病 (CKD) 和长期COVID之间的关联仍然未得到报道.
- 了解这种联系对于管理COVID-19后的健康结果至关重要.
研究的目的:
- 调查基线CKD和长期COVID风险之间的关联.
- 检查COVID-19后发生的CKD或功能下降是否与长期COVID有关.
主要方法:
- 利用来自59个美国医疗保健系统 (N3C COVID Enclave) 对急性COVID-19 (2021年10月至2023年9月) 的成年人的数据.
- 员工倾向性得分匹配分析基线CKD/ESKD和长期COVID风险.
- 在没有基线脏疾病的患者中评估发生的CKD/ESKD和eGFR下降.
主要成果:
- 基线CKD/ESKD,包括轻度病例,显著增加了长期COVID风险 (sHR 1.13-1.15).
- 在没有基线CKD的患者中,发生CKD/ESKD (sHR 1.65) 和eGFR下降 (sHR 1.21) 与长期COVID相关.
结论:
- 慢性脏病,即使是轻微的,也是患长期COVID的重要危险因素.
- 长期的COVID与新病的发展和感染后功能下降有关.
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