激素治疗与COVID-19中的结果的关联
Carol L Kuhle1, Dietlind L Wahner-Roedler1, Karen M Fischer2
1Division of General Internal Medicine, Department of Medicine.
Menopause (New York, N.Y.)
|August 5, 2025
概括
绝经前期和绝经后妇女使用激素治疗并没有显著影响COVID-19的严重结果,如住院治疗或死亡. 当前荷尔蒙疗法使用者与过去或从未使用者相比,表现出类似的风险,表明没有额外的危害.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 传染病流行病学 传染病流行病学
- 临床研究是临床研究.
背景情况:
- 荷尔蒙疗法 (HT) 是通常被经期绝经和绝经后妇女使用的.
- 在这个人口群体中,HT对COVID-19严重性的影响尚不清楚.
- 了解潜在的关联对于患者护理和公共卫生至关重要.
研究的目的:
- 检查激素治疗 (HT) 使用与严重的COVID-19结果之间的关系.
- 根据HT状态,比较患有COVID-19的绝经前和绝经后妇女的急诊室访问,住院和死亡.
主要方法:
- 使用罗切斯特流行病学项目的回顾性队列研究.
- 包括2020年3月至9月期间确诊COVID-19的40-65岁女性.
- 现在的HT用户和过去的/从未使用者之间的严重结果 (急诊室访问,住院,死亡) 的比较,用后勤回归分析.
主要成果:
- 这项研究包括689名女性,平均年龄为56岁.
- 过去/从未使用过HT的用户年龄较大,患有更严重的COVID-19风险因素,糖尿病发病率更高.
- 与过去的/从未使用过的用户相比,当前的HT用户经历了类似的严重COVID-19结果率和风险,即使在调整后也是如此.
结论:
- 目前和过去/从未使用激素治疗的用户之间没有观察到严重的COVID-19结果的显著差异.
- 研究结果表明,激素治疗的使用与患有严重COVID-19症状的女性的伤害增加无关.
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