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揭开肥胖和高潮症状之间的关联:一个通用的结构方程建模方法
Sócrates Aedo1, Juan Enrique Blümel2, María Soledad Vallejo3
1Department of Medicine, School of Medicine, Faculty of Medicine, Universidad Finis Terrae, Santiago de Chile, Chile.
肥胖在绝经后妇女中显著恶化更年期症状,直接和间接地通过慢性疾病和不活动. 身体活动和教育等生活方式因素会影响症状的严重程度.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 肥胖医学 肥胖医学
- 公共卫生 公共卫生
背景情况:
- 更年期症状的严重程度会影响更年期后妇女的生活质量.
- 肥胖是老龄化人口中普遍存在的并发症.
- 了解肥胖,慢性疾病和更年期症状之间的相互作用至关重要.
研究的目的:
- 调查肥胖和更年期症状严重程度之间的直接和间接联系.
- 探索慢性疾病和身体活动在这种关系中的调解作用.
主要方法:
- 对REDLINC XII跨国研究 (n=722名绝经后妇女) 的观察性次分析.
- 使用更年期评分表 (MRS) 评估更年期症状.
- 一般化结构方程建模 (GSEM) 分析了肥胖,慢性疾病,体力活动和MRS分数之间的关系.
主要成果:
- 肥胖与较高的MRS分数 (OR=1.75) 有直接关联.
- 肥胖与MRS得分的间接关联是相当大的 (OR=19.07) 通过高血压,糖尿病,不活动和心血管/呼吸系统疾病.
- 肥胖与症状严重程度的总相关性是显著的 (OR=33.45). 身体不活动和抗抑郁药物增加了严重程度;教育,活动和激素治疗减少了它.
结论:
- 肥胖与更年期症状严重程度的增加密切相关.
- 慢性疾病和行为因素调解了肥胖症状关系.
- 建议进行进一步的纵向研究以确认因果关系.
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