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Updated: Jun 18, 2026

Evaluation of Protein–Protein Interactions using an On-Membrane Digestion Technique
07:07

Evaluation of Protein–Protein Interactions using an On-Membrane Digestion Technique

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从蛋膜中鉴定DPP-IV抑制:结构活动关系,消化稳定性和分子机制

Shasha Wang1, Zuyue Li1, Mahmoud Abou-Elsoud1,2

  • 1National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.

Journal of agricultural and food chemistry
|August 5, 2025
PubMed
概括

蛋膜 (ESM) 产生的生物活性可以抑制二乙酶-IV (DPP-IV),这是葡萄糖调节中的关键酶. 这些新型为开发功能性食品和治疗药物提供了有希望的途径.

关键词:
这是一种DPP-IV抑制.蛋蛋膜膜是什么意思分子对接的分子对接.结构 - 活动关系关系.二型糖尿病是二型糖尿病.

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Protein Digestion

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Hormonal Regulation

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Overview of Secretory Vesicles

Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
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Pancreatic Juice and Secretion

Pancreatic juice is a clear fluid produced by the pancreas, containing water, salts, sodium bicarbonate, and enzymes vital for digestion in the small intestine. It helps break down large molecules, facilitating nutrient absorption.
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Glucagon-like Receptor Agonists

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Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a significant...