Tra/Dsx-JHBP轴控制虫中的雌性特异性基因表达和卵位
Xiaoming Zhao1, Qian Ma1,2, Ti Shao1,2
1Shanxi Key Laboratory of Nucleic Acid Biopesticides, Institute of Applied Biology, Shanxi University, Taiyuan, Shanxi, China.
PLoS biology
|August 5, 2025
概括
雌性虫具有可伸缩的腹膜用于产卵,由特定的蛋白质LmAbd-1和LmAbd-6控制. 这种性变态是由青春期激素 (JH) 信号传递和性别决定途径调节的.
科学领域:
- 动物学 动物学
- 发展生物学 发展生物学
- 分子生物学分子生物学
背景情况:
- 性二态性在动物形态学和行为中普遍存在.
- 迁徙的雌性表现出独特的,可伸缩的腹部间隔膜 (ISM),这对卵至关重要.
- 在ISM中这种性二态化背后的分子机制在很大程度上是未知的.
研究的目的:
- 阐明控制雌性Locusta migratoria可扩展性ISM的分子机制.
- 为了确定关键的蛋白质和信号通路参与女性特有的腹部伸展性.
- 了解性二形态性在卵置行为中的遗传基础.
主要方法:
- 蛋白质组分析以确定ISM中的女性特异性蛋白质.
- 基因表达分析用于研究已识别的蛋白质的调节.
- 对青春期激素 (JH) 信号通路的研究.
- 对性别决定途径 (Tra-2和DSx) 的参与进行分析.
主要成果:
- 两种女性特异性蛋白质LmAbd-1和LmAbd-6被确定为ISM扩展性的主要控制者.
- 青年激素 (JH) 结合蛋白质LmJHBP调解JH信号,诱导女性ISM中的LmAbd-1和LmAbd-6表达.
- 性别决定途径 (Tra-2和DSx) 决定LmJHBP的女性特异性表达,从而调节JH信号和下游蛋白质表达.
结论:
- Tra/Dsx-JHBP轴是Locusta migratoria ISM中性二态化的关键调节途径.
- 这一途径通过调节腹部伸展性来控制女性特有的卵置行为.
- 这些发现有助于我们更好地理解昆虫的性二态和适应性进化.
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