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Updated: Sep 12, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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在CBFβ-SMMHC驱动的白血病发生需要在小鼠中增强RUNX1-DNA结合亲和力

Tao Zhen1, Yaqiang Cao2, Tongyi Dou3

  • 1Oncogenesis and Development Section, Translational and Functional Genomics , National Human Genome Research Institute, NIH, Bethesda, United States of America.

The Journal of clinical investigation
|August 5, 2025
PubMed
概括

白血病蛋白CBFβ-SMMHC通过增加RUNX1驱动癌症.

关键词:
遗传学 是一个遗传学.血液学 血液学 血液学白血病 (Leukemias) 是一种癌症.鼠标模型 鼠标模型文字转录学 (Transcriptomics) 是一个学科.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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