在健康的日本男性中,身体活动,久坐时间和精子DNA碎片化指数
Hongxuan Li1, Wen Hao1, Eri Maeda2
1Department of Public Health, Hokkaido University Faculty of Medicine and Graduate School of Medicine, Hokkaido, Japan.
Reproductive biomedicine online
|August 5, 2025
概括
较高的体力活动和较少的静坐时间与日本男性的DNA碎片化指数 (DFI) 得分较低有关. 这些生活方式因素与传统的精液参数没有关联.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 男人的健康 男人的健康
- 精子生成研究 精子生成研究
背景情况:
- 生活方式因素,包括体力活动和久坐时间,越来越多地被认为对男性生殖健康的潜在影响.
- DNA碎片化指数 (DFI) 是精子DNA完整性的标志物,对于成功受精和胚胎发育至关重要.
- 了解身体活动,久坐不动行为和精液质量之间的关系对于有关男性生育能力的公共卫生建议很重要.
研究的目的:
- 为了研究身体活动水平,久坐时间和健康日本男性的DNA碎片化指数 (DFI) 得分之间的关联.
- 为了检查身体活动,静止时间和同一个队列中的常规精液参数之间的关系.
- 提供对可修改的生活方式因素的见解,这些因素可能会影响男性生育指标.
主要方法:
- 通过使用323名健康的日本男性 (20-39岁) 的基线数据进行了横截面分析,这些男性参与了男性预孕研究和教育研究.
- 身体活动和久坐时间使用国际身体活动问卷-简单表格进行评估.
- 通过DNA碎片化指数 (DFI) 评分和传统的精液分析来评估精液质量,并根据潜在的混因素调整统计模型.
主要成果:
- 较高的总体体力活动水平与较低的DFI得分有显著的关联,在体力活动的第三和第四四分位数中观察到显著的减少.
- 与较短的静坐时间观察到较低的DFI得分趋势,静坐时间的第一四分位数与第四四分位数相比显著减少.
- 身体活动,久坐时间和常规的精液参数 (如精子数,运动性或形态) 之间没有发现显著的关联.
结论:
- 增加体力活动和减少静坐时间与改善精子DNA完整性有关,正如较低的DFI得分所示,在健康的日本男性中.
- 这些生活方式因素似乎不会影响这个人群中传统的精液参数.
- 这些发现表明,促进体力活动和减少久坐可能对男性生殖健康有益,特别是关于精子DNA完整性的研究.
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