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小分子光探针用于器官纤维化生物成像:进展,挑战和前景

Jinlong Li¹, Chen Liu¹, Xinrui Yang²

¹Jiangsu Provincial University Key Laboratory of Intelligent Medical Sensing Materials and Devices, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, 211816, PR China.

Biosensors & bioelectronics

|August 5, 2025

概括

新型光探针为监测纤维化生物标志物提供了最少的侵入性方法,解决了传统活检和成像的局限性. 这种方法有助于理解和潜在地治疗器官纤维化.

科学领域:

生物医学工程生物医学工程
分子成像学分子成像学
病理学病理学病理学

背景情况:

纤维化涉及过度的细胞外基质 (ECM) 沉积,导致器官损伤和功能障碍.
器官纤维化是一个全球性的健康问题,对医疗保健造成了重大负担.
目前的诊断方法,如活检是侵入性的,传统的成像有局限性.

研究的目的:

对纤维细胞生物标志物的当前光探针设计策略进行审查.
为了确定当前光探测器技术的技术局限性.
在纤维化研究中提出光探针开发的未来方向.

主要方法:

总结了用于关键纤维细胞生物标志物 (ROS / RNS,酶,微环境) 的光探针设计策略.
分析探测器设计,以确定技术挑战.
审查了非或最小侵入性成像技术的进展.

主要成果:

光探针提供了特定的准和潜在的低成本,微创性纤维化监测.
鉴定了当前探头设计及其应用中的局限性.
强调需要先进的成像系统来实时监测生物标志物.

结论:

光探针为纤维化诊断和治疗的传统方法提供了一个有希望的替代方案.
光探针的进一步开发可以显著推进纤维化研究.
本综述为在临床环境中应用新型探针提供了指导.

关键词:

生物标志物的检测检测.光探测器探测器可以发光.光学成像技术的使用.器官纤维化器官纤维化小分子探测器探测器

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