波多黎各与呼吸道病原体和登革热疾病严重程度的同时感染,2012-2024年
Matthew J Lozier1,2, Diego M Canabal López3, Brenda Torres-Velásquez1
1Centers for Disease Control and Prevention, San Juan, Puerto Rico.
The American journal of tropical medicine and hygiene
|August 5, 2025
概括
登革热病毒 (DENV) 与其他病原体的共感染在波多黎各的急性发烧性疾病中不常见,主要涉及呼吸道病毒. 综合性检测至关重要,因为重叠的症状使患者管理复杂化.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 将登革热病毒 (DENV) 等树状病毒感染与其他病原体区分开来是一项挑战,特别是在共感染时.
- 识别DENV共感染对于管理疾病严重程度和指导患者护理决策至关重要.
- 同感染可以使急性发烧性疾病 (AFI) 的诊断和治疗复杂化.
研究的目的:
- 在波多黎各,比较DENV单感染与DENV共感染的临床和人口特征.
- 为了确定与DENV.共感染的病原体的流行率和类型.
- 评估DENV共感染对疾病严重程度和住院治疗的影响.
主要方法:
- 来自波多黎各 Sentinel 增强型登革热监测系统 (2012-2024) 的数据分析.
- 使用核酸检测 (实时RT-PCR) 和血清学进行病原体鉴定.
- 使用曼-惠特尼-威尔科克森,奇平方和费舍尔精确测试对人口统计和临床特征的统计比较.
主要成果:
- 在50189名参与者中,1218名 (2.4%) 患有DENV感染,其中46名 (3.8%) 是共感染.
- 最常见的共感染病原体是腺病毒,甲型流感,人体甲肺病毒和呼吸道同胞病毒.
- DENV共感染与年轻的年龄和鼻和咳等症状有关;严重的登革热指标与共感染没有显著关联.
结论:
- 在波多黎各的AFI病例中,DENV共感染是罕见的,主要涉及呼吸道病毒.
- DENV和共感染病毒之间的重叠症状可能会使临床诊断和管理复杂化.
- 在有共同循环的树状病毒和呼吸道病毒的地区,全面的病原体检测至关重要.
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